Gardner Syndrome

A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.

Also Known As:

Gardner's Syndrome; Gardner Syndromes; Gardner's Syndromes; Gardners Syndrome; Syndrome, Gardner; Syndrome, Gardner's; Syndromes, Gardner; Syndromes, Gardner's

Neoplasms: 1361496
- Hereditary Neoplastic Syndromes: 115
  - Adenomatous Polyposis Coli: 3472
    - Gardner Syndrome: 152
- Neoplasms by Site: 4
  - Digestive System Neoplasms: 251
    - Gastrointestinal Neoplasms: 4515
      - Intestinal Neoplasms: 529
        Colorectal Neoplasms: 76245
        Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
- Neoplasms by Histologic Type: 2
  - Glandular and Epithelial Neoplasms: 445
    - Adenoma: 20941
      - Adenomatous Polyps: 768
        Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
Digestive System Diseases: 1068
- Gastrointestinal Diseases: 6062
  - Gastrointestinal Neoplasms: 4515
    - Intestinal Neoplasms: 529
      - Colorectal Neoplasms: 76245
        Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
  - Intestinal Diseases: 1640
    - Intestinal Neoplasms: 529
      - Colorectal Neoplasms: 76245
        Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
    - Colonic Diseases: 360
      - Colorectal Neoplasms: 76245
        Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
    - Intestinal Polyposis: 139
      - Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
- Digestive System Neoplasms: 251
  - Gastrointestinal Neoplasms: 4515
    - Intestinal Neoplasms: 529
      - Colorectal Neoplasms: 76245
        Adenomatous Polyposis Coli: 3472
        Gardner Syndrome: 152
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Congenital Abnormalities: 26404
  - Multiple Abnormalities: 213
    - Gardner Syndrome: 152
- Inborn Genetic Diseases: 12342
  - Hereditary Neoplastic Syndromes: 115
    - Adenomatous Polyposis Coli: 3472
      - Gardner Syndrome: 152

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